Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion
نویسندگان
چکیده
منابع مشابه
The N-terminal LIM domain negatively regulates the kinase activity of LIM-kinase 1.
LIM-kinase 1 (LIMK1, where LIM is an acronym of the three gene products Lin-11, Isl-1 and Mec-3) is a serine/threonine kinase that phosphorylates cofilin and regulates actin cytoskeletal reorganization. LIMK1 contains two LIM domains and a PDZ (an acronym of the three proteins PSD-95, Dlg and ZO-1) domain in the N-terminal half and a kinase domain in the C-terminal half. In this study we examin...
متن کاملA role for LIM kinase in cancer invasion.
In this study, we show that LIM kinase 1 (LIMK1), a critical regulator of actin dynamics, plays a regulatory role in tumor cell invasion. We found that the level and activity of endogenous LIMK1 is increased in invasive breast and prostate cancer cell lines in comparison with less invasive cells. Overexpression of LIMK1 in MCF-7 and in MDA-MB-231 human breast cancer cell lines increased their m...
متن کاملDownregulation of LIM kinase 1 suppresses ocular inflammation and fibrosis
PURPOSE The purpose of this study was to determine if downregulation of LIM kinase 1 (LIMK1) by genetic deletion or direct application of LIMK1-targeted siRNA could suppress TGF-beta mediated ocular inflammation and fibrosis. METHODS LIMK1 specific siRNAs designed from the human sequence were transfected into human corneal fibroblasts in culture. Immunofluorescence and immunoblotting were per...
متن کاملTargeting LIM kinase in cancer and neurofibromatosis
Neurofibromatosis type 1 is among the most common inherited diseases, affecting 1 in 3500 individuals. The phenotype of this autosomal-dominant disorder is highly variable and can be mild or severe. Symptoms might include café-au-lait spots, low intelligence, specific learning difficulties and behavioral problems, bone deformations, and various neurological syndromes. These patients are prone t...
متن کاملPalmitoylation of LIM Kinase - 1 Ensures Spine - specific Actin Polymerization and 2 Morphological Plasticity 3 4
20 Precise regulation of the dendritic spine actin cytoskeleton is critical for 21 neurodevelopment and neuronal plasticity, but how neurons spatially control actin 22 dynamics is not well defined. Here, we identify direct palmitoylation of the actin 23 regulator LIM kinase-1 (LIMK1) as a novel mechanism to control spine-specific actin 24 dynamics. A conserved palmitoyl-motif is necessary and s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Research
سال: 2019
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-19-1237